Method for measuring hyaluronic acid

Chemistry: analytical and immunological testing – Biospecific ligand binding assay

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436503, 436509, 436518, 435 71, 435 78, 435 792, 435 794, 435 793, 435967, 530356, 530357, 53038823, G01N 33566, G01N 33567, G01N 3353, A61K 3712

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053786378

ABSTRACT:
A method for measuring hyaluronic acid in a biological sample which comprises (a) coating a solid support with hyaluronic acid; (b) incubating the sample with cartilage proteoglycan; (c) exposing the incubated sample to the coated solid support; (d) then exposing the coated solid support to a keratan sulfate-reactive antibody; (e) determining the amount of antibody linked to keratan sulfate; and (f) correlating the amount of antibody linked to the keratan sulfate to the amount of hyaluronic acid in the sample.

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Hascall, V. C., et al. "Proteoglycans: Isolation and Characterization" Methods in Enzymology, vol. 82, 769-785 (1982).
Keiser, Anal. Biochem. Feb. 1, 1987, 160 (2) pp. 462-467 abstract only.
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