Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-06-07
2011-06-07
Cheu, Jacob (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007200, C436S518000
Reexamination Certificate
active
07955809
ABSTRACT:
This invention provides a method for measuring human megalin that can be performed in a simpler manner within a shorter period of time than is possible with conventional techniques, and that can also quantify human megalin. This invention also provides a method that enables diagnosis of functional diseases, which are specific to cells, tissues, or organs, in a site-directed manner at an early stage. Measurement of human megalin enables detection of a disease in an organ in which megalin expression is observed.
REFERENCES:
patent: 2004/0204357 (2004-10-01), Brautigam et al.
patent: 2004/0235161 (2004-11-01), Tabata et al.
patent: 4-351962 (1992-12-01), None
patent: 8-105889 (1996-04-01), None
patent: WO 03/102493 (2003-12-01), None
Jordan (The Protein Protocol Handbook, second edition, edited by Walker, year 2000, p. 1083-1088).
Willnow et al. (PNAS 1996 vol. 93 p. 8460-8464).
Marion De Jong PhD et al., “Megalin Is Essential for Renal Proximal Tubule Reabsorption of111In-DTPA-Octreotide”, The Journal of Nuclear Medicine, vol. 46, No. 10, Oct. 2005, pp. 1696-1700.
Supplementary European Search Report EP 07 74 0098 dated Aug. 24, 2009.
Arvi-Matti Kuusniemi et al., “Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change”, Kidney International, vol. 68, (2005) pp. 121-132.
Anthony G. W. Norden et al., “Urinary Megalin Deficiency Implicates Abnormal Tubular Endocytic Function in Fanconi Syndrome”, J. Am. Soc. Nephrol. 13: 125-133, 2002.
K. Kobayashi et al., “Conditions for Solubilization of Tamm-Horsfall Protein/Uromodulin In Human Urine and Establishment of a Sensitive and Accurate Enzyme-Linked Immunosorbent Assay (ELISA) Method”, Archives of Biochemistry and Biophysics, vol. 388, No. 1, Apr. 1, 2001, pp. 113-120.
C.J. Ilsa Raats et al., “Reduction in Glomerular Heparan Sulfate Correlates with Complement Deposition and Albuminuria in Active Heymann Nephritis”, J. Am. Soc. Nephrol. 10: 1689-1699, 1999.
Miura Shuhei
Ogasawara Shinya
Saito Akihiko
Takeda Tetsuro
Bent Stephen A.
Cheu Jacob
Denka Seiken Co., Ltd.
Foley & Lardner LLP
Niigata University
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