Method for measuring glucose concentration in blood using...

Surgery – Diagnostic testing – Measuring or detecting nonradioactive constituent of body...

Reexamination Certificate

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Reexamination Certificate

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07974669

ABSTRACT:
The objective of the present invention is to provide a method and instrument for measuring glucose concentration in blood using infrared spectroscopy. Glucose concentration in blood is measured based on an integrated value obtained by measuring an absorption spectrum that includes the wavenumber range of 1020-1040 cm−1, and by integrating the intensity of absorption of the wavenumber range of 1020-1040 cm−1within the absorption spectrum. Alternatively, a glucose concentration in blood is measured based on an integrated value through measuring an absorption spectrum including the wavenumber range of 1010-1050 cm31 1; obtaining a second-derivative spectrum by calculating a second derivative of the absorption spectrum that includes the wavenumber range of 1010-1050 cm−1in the absorption spectrum; determining an integration range based on the second derivative spectrum; and then obtaining the integrated value by integrating the intensity of absorption based on this determined integration range.

REFERENCES:
patent: 6421548 (2002-07-01), Berman et al.
patent: 2004/0147034 (2004-07-01), Gore et al.
patent: 2002-131228 (2002-05-01), None
patent: 2003-042948 (2003-02-01), None
patent: WO 03/069308 (2003-08-01), None
Shen et al. The Use of Fourier-Transform Infrared Spectroscopy for the Quantitative Determination of Glucose Concentration in Whole Blood; Physics in Medical Biology, vol. 48 (2003) pp. 2023-2032.
Kim et al. Determinationof Glucose in Whole Blood Samples by Mid-Infrared Spectroscopy; Applied Optics, vol. 42, No. 4 (2003) pp. 745-749.
Karatsu et al. Determination of the Glucose in Serum by the FT-IR-ATR Method; Bunseki Kagaku, vol. 54, No. 2 (2005) pp. 149-154.
Petibois et al. Determination of Glucose in Dried Serum Samples by Fourier-Transform Infrared Spectroscopy; Clinical Chemistry, vol. 45, No. 9 (1999) pp. 1530-1535.
English Language Abstract of T. Karatsu, et al., “Determination of the Glucose in Serum by the FT-IR-ATR Method”, Bunseki Kagaku, vol. 54, No. 2, Feb. 5, 2005, abstract only.
C. Petibois, et al., “Determination of Glucose in Dried Serum Samples by Fourier-Transform Infrared Spectroscopy”, Clinical Chemistry, vol. 45, No. 9, 1999, pp. 1530-1535.
C. Petibois, et al., “Plasma Protein Contents Determined by Fourier-Transform Infrared Spectromety”, Clinical Chemistry, vol. 47, No. 4, 2001, pp. 730-738.

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