Chemistry: analytical and immunological testing – Involving kinetic measurement of antigen-antibody reaction
Reexamination Certificate
2005-08-16
2008-10-21
Chin, Christopher L (Department: 1641)
Chemistry: analytical and immunological testing
Involving kinetic measurement of antigen-antibody reaction
C422S082110, C436S164000, C436S524000, C436S525000, C436S805000
Reexamination Certificate
active
07439078
ABSTRACT:
An object of the present invention is to provide a method for measuring the dissociation rate coefficient (Kd) by surface plasmon resonance analysis without measuring the theoretical maximum amount of binding (Rmax). The present invention provides a method for measuring the dissociation rate coefficient (Kd) of the reaction between an analyte molecule immobilized on a metal surface and a molecule that interacts with the analyte molecule by assaying changes in surface plasmon resonance signals using a surface plasmon resonance measurement device, wherein the signal and the slope of the dissociation curve of the surface plasmon resonance signal curves, or the signal ratio are used to calculate the dissociation rate coefficient (Kd).
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Ogura Nobuhiko
Ohtsuka Hisashi
Chin Christopher L
FUJIFILM Corporation
Sughrue & Mion, PLLC
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