Method for measuring and reporting co-oximeter quality control r

Optics: measuring and testing – Blood analysis – Hemoglobin concentration

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356300, 356319, 356 41, 364498, 36457102, G01J 342, G01N 3349

Patent

active

058284451

ABSTRACT:
The present invention comprises methods of determining the performance of an absorbance spectrometer, and, in particular, of CO-oximeters. The methods comprise measuring the absorbance spectrum of a quality control sample and comparing it to a standard spectrum of that quality control. Instrumental error will be the primary factor contributing to the observed difference. The present method also provides techniques for converting the instrumental error manifested in the difference between the measured and standard quality control spectra into blood concentration values comparable to that of real blood. Analysis of test samples on a spectrophotometer; and calibration of the spectrophotometer is also provided.

REFERENCES:
patent: 4945062 (1990-07-01), Chiang
patent: 5243546 (1993-09-01), Maggard
de Noord, Onno E., "Multivariate Calibration Standardization", Chemometrics and Intelligent Laboratory Systems, 25 (1994) 85-97.
Lorber, Avraham, et al., "Estimation of Prediction Error for Multivariate Calibration", Journal of Chemometrics, vol. 2, (1988) 93-109.
Wang, Yongdong, et al., "Multivariate Instrument Standardization", Analytical Chemistry, vol. 63, No. 23, (Dec. 1, 1991), 2750-2756.

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