Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Reexamination Certificate
2011-06-28
2011-06-28
Cook, Lisa (Department: 1641)
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
C435S007100, C436S501000, C436S506000, C436S518000, C424S001110, C424S001210
Reexamination Certificate
active
07968306
ABSTRACT:
Methods of measuring the SFA and sPLA2activities in a mammalian subject are provided. The methods include: providing a substrate comprising a fluorescently labeled carboxylic acid and a negatively charged phospholipid in an organic solvent such as ethanol, mixing the substrate with phospholipase A2and a biological sample from the subject, and detecting the fluorescence intensity change to determine the SFA and sPLA2activity in the sample. A decrease in SFA activity in the test sample as compared to the SFA activity in the control sample indicates that the subject has developed or is about to develop inflammation. An increase in sPLA2activity in the test sample as compared to the sPLA2activity in the control sample indicates that the subject has developed or is about to develop inflammation. Further disclosed is a kit for practicing the above methods.
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Meyer Keith C.
Tsao Francis H. C.
Cook Lisa
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
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