Data processing: measuring – calibrating – or testing – Measurement system in a specific environment – Chemical analysis
Reexamination Certificate
2011-03-08
2011-03-08
Smith, Carolyn L. (Department: 1631)
Data processing: measuring, calibrating, or testing
Measurement system in a specific environment
Chemical analysis
C702S019000, C702S150000, C702S189000, C703S002000, C703S011000
Reexamination Certificate
active
07904252
ABSTRACT:
A method of easily and speedily determining what structural change is experienced by a target protein upon contact and binding of any arbitrary compound to the target protein; a method of selecting and screening a compound for use in the method; and a computer program for carrying out these methods. In one embodiment, a Saupe order matrix element of domain is obtained from atomic coordinates of domain and an axial-direction variation of NMR signal dependent upon the orientation angle of molecule in magnetic field, and the matrix is diagonalized to thereby obtain the orientation information on the domain. Using of any change of the orientation information as an indicator for structural change enables realization of the intended easy and speedy measurement of structural change of the target protein.
REFERENCES:
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patent: 2001-321192 (2000-05-01), None
patent: 2003-130823 (2001-10-01), None
patent: WO 97/18471 (1997-05-01), None
Alba et al., “NMR dipolar couplings for the structure determination of biopolymers in solution”, 2002, Progress in Nuclear Magnetic Resonance Spectroscopy, vol. 40, 2002, pp. 175-197.
Tate et al., “Molecular-orientation analysis based on alignment-induced TROSY chemical shift changes”, 2004, Journal of Magnetic Resonance, vol. 171, pp. 284-292.
Suzanne B. Shuker et al., “Discovering High-Affinity Ligands for Proteins: SAR by NMR”, Science, vol. 274, Nov. 29, 1996, pp. 1531-1534.
Ichio Shimada, “Structure Analysis of High-Molecular Proteins by NMR”, Pharmacia, vol. 31 (1995) in Japanese with partial translation, pp. 1371-1375.
A. Marquez, Esq. Juan Carlos
Hitachi , Ltd.
Smith Carolyn L.
Stites & Harbison PLLC
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