Surgery – Truss – Perineal
Patent
1979-11-13
1981-04-07
Michell, Robert W.
Surgery
Truss
Perineal
424 9, A61B 1900
Patent
active
042599474
ABSTRACT:
A method for determining the norepinephrine activity of a human brain may provide information useful to the diagnosis and treatment of affective disorders. In such a method, the norepinephrine metabolite, 3-methoxy-4-hydroxyphenylglycol, produced by the brain can be measured separately from that produced by the peripheral nervous system. A sample is taken for measuring the total body levels of the norepinephrine metabolites, 3-methoxy-4-hydroxyphenylglycol and vanillylmandelic acid. A dose of isotopically labelled norepinephrine is administered to the body of the subject. Subsequent to the administration of the labelled norepinephrine, samples are collected for measuring the total body levels of isotopically labelled metabolites, 3-methoxy-4-hydroxyphenylglycol and vanillylmandelic acid. Since vanillylmandelic acid is metabolized from norepinephrine substantially entirely in the peripheral nervous system, the brain's contribution of 3-methoxy-4-hydroxyphenylglycol can be determined.
REFERENCES:
"The Biochemical Basis of Neuropharmacology", Cooper et al., 3rd Edition, Oxford Press.
"The Pharmacology Basis of Therapeutics", Goodman et al., 5th Ed.
"The Metabolism of Circulating Norepinephrine by Human Subjects", J. of Pharmacology and Exp. Therapeutics, Maas et al., 1971.
"Differentially Labeling of Origins of Urinary Catecholamine by Dopamine C.sup.14 ", 28 Trans. Assoc. Am. Physician 256, Ebert et al., 1975.
Estimation of the Contribution of Peripheral and Central Noradonergic Neurones to Urinary 3-Methoxy-4-Hydroxy-Phenylglycol in the Rat, 13 Neuropharmacology, Karoum et al., 1974, p. 165.
"Toward a Biochemical Classification of Depressive Disorders", 35th Arch. Gen. Psychiatry, 1427 (1978), Schildkraut et al.
"Current Status of the Catecholamine Hypothesis of the Affective Disorders", Psychopharmacology, Lipton et al., 1978.
Michell Robert W.
Wallen Thomas
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