Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2005-10-04
2005-10-04
Wax, Robert A. (Department: 1653)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S320100, C435S325000
Reexamination Certificate
active
06951740
ABSTRACT:
The present invention relates to a method for mass-production of target protein, particularly to a method for mass-production of trombopoietin by regulating the expression of chaperone protein.
REFERENCES:
patent: 2005/0081256 (2005-04-01), Forsberg et al.
Raymond Davis et al., “Effect of PDI Overexpression on Recombinant Protein Secretion in CHO Cells”, Biotechnol. Prog. 2000, 16, 736-743.
Andrew J. Dorner et al., “Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells”, The EMBO Journal, vol. 11, No. 4, pp. 1563-1571, 1992.
Chung Joo Young
Hwang Sun Ok
Lee Gyun Min
Korea Advanced Institute of Science and Technology
Lucas & Mercanti LLP
Wax Robert A.
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