Method for manufacturing isoxazole derivative or...

Details Method for manufacturing isoxazole derivative or... Method for manufacturing isoxazole derivative or...

2005-10-28

2009-02-24

Saeed, Kamal A (Department: 1626)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C548S240000, C514S378000

Reexamination Certificate

active

07495107

ABSTRACT:
There is provided with a method for manufacturing an isoxazole derivative at a high yield and without discharging waste products, and a novel isoxazole derivative. An isoxazole derivative expressed by Formula (8) is produced by reacting a 1-alkyne compound expressed by Formula (7) with iron(III) nitrate in the presence of acetone or acetophenone:(where R1is an alkyl, cycloalkyl, phenyl, or other such group); and(where R2is a methyl or a phenyl).

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Ken-ichi Itoh et al., “Formation of isoxazole derivatives via nitrile oxide using ammonium cerium nitrate (CAN): a novel one-pot synthesis of 3-acetyl- and 3-benzoylisoxazole derivatives”, Tetrahedron, 60, pp. 1671-1681, 2004.
Ken-ichi Itoh et al., “A novel one-pot synthesis of 3-acetyl- and 3-benzoylisoxazole derivatives using ammonium cerium nitrate (CAN)”, Tetrahedron Letters, 43, pp. 7035-7037, 2002.
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