Method for manufacturing freeze dried dosages in a multilaminate

Details Method for manufacturing freeze dried dosages in a multilaminate Method for manufacturing freeze dried dosages in a multilaminate

1992-12-01

1994-09-06

Sipos, John

Package making

Methods

With contents treating

53453, 53393, B65B 6308

Patent

active

053436725

ABSTRACT:
An improved method for manufacturing freeze dried pharmaceutical tablets in blister packs is disclosed. Liquid dosages are introduced into a multilayer laminated blister sheet having an impermeable intermediate layer that is positioned between first and second outer layers, each of which has substantially the same coefficient of thermal expansion. The properties of the outer layers of the blister sheet are such that there are no inter-layer stresses that will cause curvature of the blister sheet when it is subjected to temperature changes during the freezing and freeze drying steps. Following the introduction of the dosages into the depressions of the blister sheet, the dosages are frozen and freeze dried. A lidding sheet is then attached to the blister sheet to seal the solid dosages into the blister pack.

REFERENCES:
patent: 3526186 (1970-09-01), Cornelius
patent: 3890448 (1975-06-01), Ito
patent: 3892058 (1975-07-01), Komatsu et al.
patent: 4085244 (1978-04-01), Stillman
patent: 4096309 (1978-06-01), Stillman
patent: 4214029 (1980-07-01), Barnes
patent: 4223512 (1980-09-01), Buchner
patent: 4224779 (1980-09-01), Guedet
patent: 4268531 (1981-05-01), Whiting, Jr.
patent: 4278716 (1981-07-01), Buchner et al.
patent: 4291085 (1981-09-01), Ito et al.
patent: 4305502 (1981-12-01), Gregory et al.
patent: 4309466 (1982-01-01), Stillman
patent: 4310578 (1982-01-01), Katsura et al.
patent: 4754597 (1988-07-01), Buxton et al.
patent: 4928474 (1990-05-01), Schirmer

Affiliated with

Also associated with

Rating

Method for manufacturing freeze dried dosages in a multilaminate does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method for manufacturing freeze dried dosages in a multilaminate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for manufacturing freeze dried dosages in a multilaminate will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1321668