Method for manufacturing dipeptides

Details Method for manufacturing dipeptides Method for manufacturing dipeptides

1980-04-01

1981-08-18

Phillips, Delbert R.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Using tissue cell culture to make a protein or polypeptide

2601125R, C12P 2102, C07C10352

Patent

active

042847214

ABSTRACT:
An improvement in a method for manufacturing dipeptides from an N-substituted aspartic acid and a phenylalanine lower alkyl ester. The two starting materials are allowed to react with each other in the presence of an immobilized metallo-proteinase in an organic solvent immiscible with water. The enzyme can be recovered for reuse thereof. The loss of materials due to the hydrolysis of the phenylalanine lower alkyl ester is reduced, so that use of the phenylalanine lower alkyl ester in a nearly stoichiometric quantity suffices for the reaction to ensure an improved yield and reduction in cost of industrial production.

REFERENCES:
patent: 3972773 (1976-08-01), Isowa et al.
patent: 4119493 (1978-10-01), Isowa et al.
A. M. Kibanov et al., Biotechnology and Bioengineering, 19, 1351-1361 (1977).
R. Okachi et al., Kagaku to Seibutsu 16 (8) 536-546 (1978).

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