Method for manufacture of THIP

Details Method for manufacture of THIP Method for manufacture of THIP

2008-05-13

2008-05-13

Seaman, Margaret D. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

active

10570551

ABSTRACT:
The present invention relates to a new method of preparing gaboxadol (THIP), which is useful for treating sleep disorders. In particular a method of preparing THIP comprising reacting a compound of formula (8b) or a salt thereof with an acid, typically a mineral acid, to obtain THIP as an acid addition salt. The present invention also relates to several intermediates

REFERENCES:
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patent: 0840601 (1998-05-01), None
Krogsgaard-Larsen et al., Acta Chemica Scandinavica B, “Muscimol analogues. II. synthesis of some bicyclic 3-isoxazolo Zwitterions”, 1977, vol. 31., pp. 584-588.
Database Registery Online; Chemical Abstracts Service, Colombus, Ohio, US; XP002308640, retrieved from STN, 85118-32-7.
Erminio Costa et al., Trends in Pharmacological Sciences including Toxicological Sciences 1996, 17, pp. 192-200.

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