Method for manufacture of N-formylaspartic anhydride

Details Method for manufacture of N-formylaspartic anhydride Method for manufacture of N-formylaspartic anhydride

1984-03-15

1985-10-29

Jiles, Henry R.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D30722

Patent

active

045501807

ABSTRACT:
In a method for the manufacture of N-formylaspartic acid anhydride which comprises reacting a mixture of aspartic acid, formic acid and acetic anhydride in the presence of an entraining organic solvent, the improvement comprising adding to the mixture, prior to or during the course of reaction, an oxide, hydroxide, or a salt of a metal. The above compound is used as an intermediate in the manufacture of alpha-L-aspartyl-L-phenylalanine methyl ester which is a sweetening agent.

REFERENCES:
patent: 4508912 (1985-04-01), Yamatani et al.

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