Method for making valproic acid derivatives

Details Method for making valproic acid derivatives Method for making valproic acid derivatives

1992-09-18

1995-08-08

Kim, Kay K. A.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Chemical modification or the reaction product thereof, e.g.,...

530362, 530363, 530367, 530400, 530403, 530406, 436543, 562553, 562590, C07K 1700, G01N 33531, C07C 5500, C07C22700

Patent

active

054400236

ABSTRACT:
A method for making a valproic acid derivative comprising a functionalized spacer arm attached to a .delta. carbon atom of a valproic acid molecule is disclosed. The method proceeds by attaching a spacer arm joined to an inorganic moiety to a valproic acid precursor to make an alkylated compound, derivatizing the alkylated compound in a liquid medium to make the valproic acid derivative, and then separating the valproic acid derivative from the liquid medium. The valproic acid derivative can be used to make an immunoreactive valproic acid conjugate.

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patent: 5168057 (1992-12-01), Oh et al.
patent: 5196351 (1993-03-01), Harris et al.

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