Method for making tissue plasminogen activator

Details Method for making tissue plasminogen activator Method for making tissue plasminogen activator

1988-04-25

1992-01-07

Schwartz, Richard A.

Chemistry: molecular biology and microbiology

Enzyme , proenzyme; compositions thereof; process for...

Hydrolase

435212, 435219, 4352402, 4352403, C12N 1500, C12N 948, C12N 964

Patent

active

050791591

ABSTRACT:
Eucaryotic cells cotransformed with product and selection genes yield considerably greater quantities of product after a novel subcloning strategy is employed: Transformants are identified for product yield, cultured under selection pressure and the progeny screened for product yield. Novel transformation vectors contain directly ligated selection and product genes and/or eucaryotic promoters.

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