Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Patent
1983-09-19
1985-02-26
Brust, Joseph Paul
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
548533, C07D20712
Patent
active
045019010
ABSTRACT:
A method is provided for making substituted prolines of the structure ##STR1## wherein X is lower alkyl or aryl, R is H, lower alkyl or an alkali metal and Z is an N-protecting group, which method includes the step of reacting a compound of the structure ##STR2## wherein Z and R are as defined above and Q is Br. tosyloxy or mesylate, with an organic copper lithium compound of the structure
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Brandt Steven
Floyd David
Moniot Jerome L.
Thottathil John K.
Brust Joseph Paul
E. R. Squibb & Sons Inc.
Levinson Lawrence S.
Rodney Burton
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