Method for making intermediates useful in the synthesis of retro

Details Method for making intermediates useful in the synthesis of retro Method for making intermediates useful in the synthesis of retro

1995-05-25

1997-07-15

Dentz, Bernard

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitriles

560 27, 560115, 560159, 556410, 556412, C07D25300

Patent

active

056485115

ABSTRACT:
A synthesis is described for intermediates which are readily amenable to the large scale preparation of hydroxyethylurea-based chiral HIV protease inhibitors. The method includes forming a diastereoselective epoxide or cyanohydrin from a chiral alpha amino aldehyde.

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