Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-08-08
2006-08-08
Mosher, Mary E. (Department: 1648)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S069700, C435S068100, C530S303000, C530S305000
Reexamination Certificate
active
07087408
ABSTRACT:
Novel insulin precursors and insulin precursor analogs having a mini C-peptide comprising at least one aromatic amino acid residue have an increased folding stability. The novel insulin precursors and insulin precursor analogs can be expressed in yeast in high yields and are preferably not more 15 amino acid residues in length. Also provided are polynucleotide sequences encoding the claimed precursors or precursor analogs, and vectors and cell lines containing such polynucleotide sequences.
REFERENCES:
patent: 5962267 (1999-10-01), Shin et al.
patent: 6875741 (2005-04-01), Pillutla et al.
patent: 0055945 (1981-12-01), None
patent: 0 163 529 (1985-12-01), None
patent: 0347845 (1989-06-01), None
patent: 0741188 (1996-05-01), None
patent: WO 95/16708 (1995-06-01), None
Pfeffer et al., Ann. Rev. Biochem., vol. 56, pp. 829-852 (1987).
Frank et al., Rich & Gross, pp. 729-739 (1981).
Chan et al., Proc. Natl, Acad. Sci, vol. 78. No. 9, pp. 5401-5405 (1981).
Thim et al., Proc. Natl, Acad. Sci, vol. 83, pp. 6766-6770 (1986).
Johnson, Ann. Rev. Biophys. Chem, vol. 17, pp. 145-166 (1988).
Pace, CRC Critical Reviews in Biochemistry, vol. 3, pp. 1-43 (1975).
Seung-Gu Chang et al., Biochemical Journal, vol. 329, pp. 631-635 (1998).
Howey et al., Diabetes, vol. 43(3), pp. 396-402 (1994).
Kaarsholm Niels C.
Kjeldsen Thomas Borglum
Ludvigsen Svend
Bork Richard W.
Green Reza
Mosher Mary E.
Novo Nordisk A S
Smith Len S.
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