Method for making fluorine labeled L-Dopa

Details Method for making fluorine labeled L-Dopa Method for making fluorine labeled L-Dopa

2006-04-04

2006-04-04

Dentz, Bernard (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

C560S029000

Reexamination Certificate

active

07022872

ABSTRACT:
The invention relates to a method for preparing F-Dopa and18F-Dopa and intermediates that are useful in the method. The invention is a method that synthesizes F-Dopa and18F-Dopa in good yield with high enantiopurity without the need for further transformations. The method includes the step of reacting a benzaldehyde derivative with a phosphonic acid derivative to produces an olefin intermediate that can be asymmetrically hydrogenated to produce the desired enantiomer.

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