Drug – bio-affecting and body treating compositions – In vivo diagnosis or in vivo testing – Ultrasound contrast agent
Patent
1997-07-02
1999-01-05
Hollinden, Gary E.
Drug, bio-affecting and body treating compositions
In vivo diagnosis or in vivo testing
Ultrasound contrast agent
A61B 5055
Patent
active
058558659
ABSTRACT:
Elastic protein microspheres, filled with water insoluble gases, have been produced by ultrasound and mechanical cavitation without the present of oxygen. The microspheres are highly echogenic. The microspheres exhibit greatly enhanced static pressure stability, up to 40 psig. The microspheres are resistant to coalescence and to expansion due to differential gas diffusion. The microspheres are resistant to collapse when suspended in a gas-depleted aqueous solution.
REFERENCES:
patent: 4572203 (1986-02-01), Feinstein
patent: 4774958 (1988-10-01), Feinstein
patent: 4832941 (1989-05-01), Berwing et al.
patent: 4844882 (1989-07-01), Widder et al.
patent: 4957656 (1990-09-01), Cerny et al.
patent: 5147631 (1992-09-01), Glajch et al.
patent: 5149319 (1992-09-01), Unger
patent: 5190982 (1993-03-01), Erbel et al.
patent: 5205290 (1993-04-01), Unger
patent: 5271928 (1993-12-01), Schneider et al.
patent: 5281408 (1994-01-01), Unger
patent: 5310540 (1994-05-01), Giddey et al.
patent: 5362478 (1994-11-01), Desai et al.
patent: 5393524 (1995-02-01), Quay
patent: 5409688 (1995-04-01), Quay
patent: 5413774 (1995-05-01), Schneider et al.
patent: 5439686 (1995-08-01), Desai et al.
patent: 5456900 (1995-10-01), Unger
patent: 5498421 (1996-03-01), Grinstaff et al.
patent: 5505932 (1996-04-01), Grinstaff et al.
patent: 5508021 (1996-04-01), Grinstaff et al.
patent: 5512268 (1996-04-01), Grinstaff et al.
patent: 5527521 (1996-06-01), Unger
patent: 5529766 (1996-06-01), Klaveness et al.
patent: 5531980 (1996-07-01), Schneider et al.
patent: 5536490 (1996-07-01), Klaveness et al.
patent: 5540909 (1996-07-01), Schutt
patent: 5547656 (1996-08-01), Unger
patent: 5556610 (1996-09-01), Yan et al.
patent: 5558094 (1996-09-01), Quay
patent: 5558853 (1996-09-01), Quay
patent: 5558854 (1996-09-01), Quay
patent: 5558855 (1996-09-01), Quay
patent: 5573751 (1996-11-01), Quay
L.C. Clark et al., "Response of the Rabbit Lung as a Criterion of Safety for Fluorocarbon Breathing and Blood Substitutes", Biomaterials, Artif. Cells Immob. Biotech. 20:1085-1099, 1992.
N. de Jong et al., "Quantification of transpulmonary echocontrast effects", Ultrasound Med. Biol. 19 (4) pp.279-288, 1993.
N. de Jong et al., "Absorption and Scatter of Encapsulated Gas Filled Microspheres: Theoretical Considerations and Some Measurements", Ultrasonics30:95-103, 1992.
R. Gramiak et al., "Echocardiography of the Aortic Root", Investigative Radiology 3:356-366, 1968.
M.W. Grinstaff et al., "Air-Filled Proteinaceous Microbubbles: Synthesis of an Echo-Contrast Agent", Proc. Natl. Acad. Sci. 88:7708-7710, 1991.
W.H. Lee et al., "Structural Effects on Blood Proteins at the Gas-Blood Interface", Federation Proceedings 30:1615-1622, 1971.
H. Lincoff et al., "The Perfluorocarbon Gases in the Treatment of Retinal Detachment", Opthalmology 90:546-551, 1983.
R.S. Meltzer et al., "Clinical Note: Why Do the Lungs Clear Ultrasonic Contrast?", Ultrasound in Medicine and Biology 6:263-269, 1980.
E.S. Munson, "Effect of Nitrous Oxide on the Pulmonary Circulation During Venous Air Embolism", Anesth. Analg. 50:785-793, 1971.
J. Ophir et al., "Contrast Agents in Diagnostic Ultrasound", Ultrasound in Medicine and Biology 15(4):319-333, 1989.
M. Pekna et al., "Evidence for iC3 Generation During Cardiopulmonary Bypass as the Result of Blood-Gas Interaction", Clin. Exp. Immunol. 91:404-409, 1993.
R.G. Presson et al., "Effect of Ventilation with Soluble and Diffusible Gases on the Size of Air Emboli", J. Appl. Physiol. 70:1068-1074, 1991.
M. Schneider et al., "Polymeric Microballoons as Ultrasound Contrast Agents: Physical and Ultrasonic Properties Compared with Sonicated Albumin", Investigative Radiology, 27:134-139, 1992.
K. S. Suslick et al., "Protein Microencapsulation of Nonaqueous Liquids", J. Am. Chem. Soc., 112:7807-7809, 1990.
W.G. Swalbach et al., "Use of a New Gas, Sulfur Hexafluoride, SF6, in Pneumoperitoneum", Amer. Rev. Tubercul. Pulmon. Dis. 76:1063-1070, 1957.
J.B. Echols, "Filtration of polymer viscosified fluids" Adv. Filtr. Sep. Tech. ( 1990) 1:108-110.
A letter dated Feb.19, 1996, addressed to Tom Ciotti, Esq., Morrison & Foerster and signed by karel J. Lambert.
Hamilton Kenneth
Hulle Carl
Jablonski Edward G.
Lambert Karel J.
Lohrmann Rolf
Hollinden Gary E.
Molecular Biosystems, Inc.
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