Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Matrices
Patent
1995-06-06
1998-08-04
Kishore, Gollamudi S.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Matrices
424486, 424489, 424490, 424491, 424499, 435174, 435177, 435180, 435182, 43524022, 264 41, 514866, A61K 948, A61K 950, C12N 1100
Patent
active
057889880
ABSTRACT:
The present invention is directed to a macrocapsule for encapsulating microcapsules containing biologically active material, such as living cells or free living cells, to make the system more biocompatible by decreasing the surface area and surface roughness of microencapsulated biological materials; increasing mechanical stability of microencapsulated biological materials; enhancing cytoprotectivity by increasing diffusion distance of encapsulated biological material from cytotoxins secreted in vivo; providing retrievability of microencapsulated material; and providing a system of sustained release of the cellular products. The method for producing such a macrocapsule containing the microcapsules is also disclosed.
REFERENCES:
patent: 4708861 (1987-11-01), Popescu
patent: 5084350 (1992-01-01), Chang
Desai Neil P.
Heintz Roswitha E.
Soon-Shiong Patrick
Kishore Gollamudi S.
Reiter Stephen E.
Vivorx Inc.
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