Method for making conjugate moieties capable of chelating parama

Details Method for making conjugate moieties capable of chelating parama Method for making conjugate moieties capable of chelating parama

1995-02-03

1996-11-05

Kumar, Shailendra

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562426, 562555, 562561, 562564, 562565, 5483181, 5483191, 5483195, 534797, C07C22904, C07C32114, C07D23304

Patent

active

055719406

ABSTRACT:
In this method, one attaches one or more chelatant molecules to a mono- or polyamino intermediate compound I which is temporarily immobilized on a solid phase by a splittable bond. Thereafter, said bond is split to release the desired conjugate moiety, whereby a reactive site is generated at the splitting site. The conjugate can be coupled to a protein homing factor using said reactive site; the latter being single per chelatant molecule, undesirable cross-linking during conjugation is substantially avoided.

REFERENCES:
patent: 4385169 (1983-05-01), Kato et al.
patent: 5087616 (1992-02-01), Myers et al.
Chemical Abstract, 94(21):172633, 1981.
Modline Abstract, AN 91248849, 1981.
Chemical Abstract, 112(7):51816, 1986.

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