Compositions: coating or plastic – Coating or plastic compositions – Pore forming
Patent
1976-09-07
1980-03-18
Hoag, W. E.
Compositions: coating or plastic
Coating or plastic compositions
Pore forming
106124, 106155, 2601237, 264 28, 264 41, B29D 2700, C07G 700, C07G 706
Patent
active
041938135
ABSTRACT:
Method for making a collagen sponge including the following steps. Native collagen form of fibrillar protein is comminuted and homogenized in an acid environment; noncollagenous material is removed and residual collagen is mixed with water the pH of the resulting slurry is adjusted to 4.5 to 5.0 by the addition of acetic acid; gluteraldehyde is then added and the slurry poured into molds and frozen at approximately -10.degree. centigrade for approximately 20 hours. The frozen mass is then thawed, washed, and immersed in a wash of pH 8 to 9 for approximately 2 hours at 20.degree. centigrade. Sufficient reducing agent is added to the wash to create excess reducing equivalents. The sponge is then immersed in a buffer solution of pH 4 to 5 for a time sufficient to equilibrate to uniform pH. The sponge formed by the above method is then moistended and self-administered in the upper vault of the vagina proximal to the cervix. The sponge is then retained for a desired period, usually several days to one month.
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Hoag W. E.
Medi-Coll, Inc.
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