Method for making cocaine receptor binding ligands and intermedi

Details Method for making cocaine receptor binding ligands and intermedi Method for making cocaine receptor binding ligands and intermedi

1995-07-31

2000-09-26

Hollinden, Gary E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

In an organic compound

546124, 546125, 546132, A61K 5104, C07D45102, C07D40100

Patent

active

061239178

ABSTRACT:
An improved method for preparation of cocaine receptor binding ligands is provided. The method calls for the preparation of the silylaryl intermediate prepared from phenyl trimethylsilane and a anhydroecgonine methyl ester appropriately substituted. The intermediate is prepared in high purity and can be directly converted to the binding ligand by iodine substitution.

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Carroll et al., J. Med. Chem., 34, pp. 2719-2725, 1991.
Jacob et al., Synthesis, pp. 611-614, Jun. 1993.

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