Method for making certain pyrano[3',4':6,7]indolizino-[1,2-B]qui

Details Method for making certain pyrano[3',4':6,7]indolizino-[1,2-B]qui Method for making certain pyrano[3',4':6,7]indolizino-[1,2-B]qui

1990-09-28

1992-10-13

Cintins, Marianne M.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D47104

Patent

active

051552256

ABSTRACT:
A method for making 8-methyl-7-(1-oxopropyl)indolizino[1,2-b]quinolin-9(11H)-ones from 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12 H)-diones, said method being graphically illustrated as follows: ##STR1##

REFERENCES:
Kingsbury, "Chemical Rearrangement of Comptothecin . . . ", Tetrahedron Lett. 29(52), 6847-50, 1988.
Hertzberg, "Modification of the hydroxylactone ring . . . ", J. Med. Chem. 32(3) 715-20, 1989.

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