Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Using tissue cell culture to make a protein or polypeptide
Patent
1995-06-06
1999-03-02
Feisee, Lila
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Using tissue cell culture to make a protein or polypeptide
435332, 4241521, 4241841, 5303882, 5303891, A61K 39395
Patent
active
058769730
ABSTRACT:
Disclosed is the characterization and purification of DNA encoding numerous polypeptides factors useful for the inhibition of cell (particularly, Schwann cell) proliferation. These factors are useful for the treatment of neural tumors. Also disclosed are the DNA sequences encoding novel polypeptides which may have use as agents which inhibit cell proliferation. Methods for the synthesis, purification, and testing of both known and novel polypeptides for their use as therapeutic and diagnostic aids in the treatment of diseases are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes. Such probes have diagnostic and therapeutic use in diseases involving neural and glial cells.
REFERENCES:
patent: 4935341 (1990-06-01), Bargmann et al.
patent: 4968603 (1990-11-01), Slamon et al.
patent: 5367060 (1994-11-01), Vandlen et al.
patent: 5530109 (1996-06-01), Goodearl et al.
Brockes et al., "The neuron as a source of mitogen", Development in the Nervous System, Garrod and Feldman, eds., pp. 309-327 (1980).
Davis et al., "Isolation and characterization of a neu protein-specific activating factor from human ATL-2 cell conditioned medium" Biochem. Biophys. Res. Communications 179:1536-1542 (1991).
Holmes et al., "Identification of Heregulin, a Specific Activator of p185erbB2" Science 256:1205-1210 (1992).
Huang et al., "Purification and Characterization of the neu/erb B2 Ligand-Growth Factor from Bovine Kidney" J. Biol. Chem. 257:11508-11512 (1992).
Lemke et al., "An immunochemical approach to the purification and characterization of glial growth factor", Monoclonal Antibodies to Neural Antigens, McKay et al., eds. 133-140 (1981).
Lupu et al., "Direct Interaction of a Ligand for the erbB2 Oncogene Product with the EGF Receptor and p185 erb2", Science 249:1552-1555 1990).
Tarakhovsky et al., "A 25 kDa polypeptide is the ligand for p185neu and is secreted by activated macrophages" Oncogene 6:2187-2196 (1991).
Brockes et al., "Assay and Isolation of Glial Growth Factor from the Bovine Pituitary", Methods In Enzym. 147:217-225, 1987.
Jeong et al., Dialog Medline Abs., J. Neurobiol. 22:462-74, 1991.
Jessel et al., "Induction of acetylcholine receptors on cultured skeletal muscle by a factor extracted from brain and spinal cord" PNAS USA 76:5397-5401, 1979.
Lentz et al., "Partial purification and characterization of a nerve trophic factor regulating muscle acetylcholinesterase activity" Exper. Neurology 73:542-557, 1981.
Markelonis et al., "Purification of sciatin using affinity chromatography on concanavalin A-Agarose" J. Neurochemistry 37:95-99., 1981.
Markelonis et al., Dialog Medline Abs. J. Cell Bio. 100:8-17, 1985.
Markelonis et al., Dialog Medline Abs. J. Neurochem 39:315-20, 1982.
Markelonis et al., Dialog Medline Abs. J. Biol. Chem. 255:8967-70, 1980.
Markelonis et al., Dialog Medline Abs. Dev. Biol. 89:353-61, 1982.
Markelonis et al., Dialog Medline Abs. Exp. Neurol. 58:285-95, 1978.
Markelonis et al., Dialog Medline Abs. J. Neurochem. 37:95-9, 1981.
Markelonis et al., Dialog Medline Abs. Exp. Neurol. 70:598-612, 1980.
Oh, "Neurotrophic effects of sciatic nerve extracts on muscle development in culture" Exp. Neurology 50:376-386, 1976.
Oh et al., Dialog Medline Abs. Dev. Biology 127:88-98, 1988.
Oh et al., Dialog Medline Abs. J. Histochem Cytochem 29:1205-12, 1981.
Oh et al., Dialog Medline Abs. J. Neuros. Res. 8:535-45, 1982.
Oh et al., Dialog Medline Abs. PNAS USA 77:6922-5, 1980.
Oh et al., Dialog Medline Abs. Exp. Neurol. 67:646-54, 1980.
Oh et al., Dialog Medline Abs. Science 200:337-9, 1978.
Oh et al., Dialog Medline Abs. Exp. Neurol. 46:432-8, 1975.
Podleski et al., "Nerve extract induces increase and redistribution of acetylcholine receptors on cloned muscle cells" PNAS USA 75:2035-2039, 1978.
Thibault et al., "Trophic effect of a sciatic nerve extract on fast and slow myosin heavy chain synthesis" Am. Physiological Society 0363/6143; C269-C272, 1981.
Benveniste et al., Purification and Characterization of a Human T-lymphocyte-derived Glial Growth-Promoting Factor, Proc. Natl. Acad. Sci USA 82:3930-3934, 1985.
Brockes, Assay and Isolation of Glial Growth Factor from the Bovine Pituitary, Methods in Enzymology 147:217-225, 1987.
Brockes et al., Purification and Preliminary Characterization of a Glial Growth Factor from the Bovine Pituitary, The Journal of Biological Chemistry 255:8374-8377, 1980.
Davis et al., Platelet-derived Growth Factors and Fibroblast Growth Factors are Mitogens for Rat Schwann Cells, The Journal of Cell Biology 110:1353-1360, 1990.
Dobashi et al., Characterization of a neu/c-erbB-2 Protein-Specific Activating Factor, Proc. Natl. Acad. Sci. USA 88:8582-8586, 1991.
Kimura et al., Structure, expression and function of a schwannoma-derived growth factor, Nature 348:257-260, 1990.
Lemke et al., Identification and Purification of Glial Growth Factor, The Journal of Neuroscience 4:75-83, 1984.
Lupu et al., Characterization of a Growth Factor that Binds Exclusively to the erbB-2 Receptor and Induces Cellular Responses, Proc. Natl. Acad. Sci. USA 89:2287-2291, 1992.
Peles et al., Isolation of the Neu/HER-2 Stimulatory Ligand: A 44 kd Glycoprotein That Induces Differentiation of Mammary Tumor Cells, Cell 69:205-216, 1992.
Wen et al., Neu Differentiation Factor: A Transmembrane Glycoprotein Containing an EGF Domain and an Immunoglobulin Homology Unit, Cell 69:559-572, 1992.
Yarden et al., Biochemical Analysis of the Ligand for the neu Oncogenic Receptor, Biochemistry 30:3543-3550, 1991.
Yarden et al., Growth Factor Receptor Tyrosine Kinases, Ann. Rev. Biochem. 57:443-478, 1988.
Falls et al., "ARIA, a Protein That Stimulates Acetylcholine Receptor Synthesis, Is a Member of the Neu Ligand Family", Cell, 72:801-815, 1993.
Chan et al., "Identification of a Competative HGF Antagonist Encoded by an Alternative Transcript" Science 254:1382-1385, 1991.
Goodearl et al., "Identification and Purification of Glial Growth Factor-II" J. Cell. Biochem., Supp. 0, (16 part F) 79 abstract, 1992.
Cambridge NeuroScience, Inc.
Feisee Lila
Reeves Julie E
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