Method for making an optically active diphosphine ligand

Details Method for making an optically active diphosphine ligand Method for making an optically active diphosphine ligand

1997-10-24

1999-07-13

Geist, Gary

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus containing

C07F 950

Patent

active

059229187

ABSTRACT:
The present invention provides a method for making compound (1) by reacting compound (2) with phosphine oxide (3) in the presence of a transition metal/phosphine complex and optionally reducing the reaction product: ##STR1## where n represents 0 or 1; the double line having a continuous line and a dotted line represents a double bond or a single bond such that the ring having the double line forms a naphthalene ring or an octahydronaphthalene ring with an adjacent benzene ring; Tf represents a trifluoromethanesulfonyl group; and Ar represents a phenyl group, a substituted phenyl group or a naphthyl group. The present invention provides an economical way to produce compound (1) as a ligand of a complex useful as a catalyst for a variety of asymmetric synthesis reactions.

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