Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Peptides containing saccharide radicals – e.g. – bleomycins – etc.
Patent
1992-12-15
1995-11-28
Warden, Jill
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Peptides containing saccharide radicals, e.g., bleomycins, etc.
530327, 530328, 530329, 530330, 530331, 564197, 564165, 562575, A61K 3800, C07K 500, C07K 700, C07K 1700
Patent
active
054709490
ABSTRACT:
A compound of the formula ##STR1## is disclosed. X is selected from the group consisting of aryl, alkyl, imidate ester, imino ester, amidine, azide, isocyanate, and dithiocarbonate. R' is a group selected from the group consisting of groups containing a hydroxyl moiety, groups containing a protected hydroxyl moiety, and groups containing an O-linked sugar. G is a carbon chain of 0-10 carbons and R is not a methyl group and is a group capable of removal under conditions compatible with glycopeptide synthesis. In a preferred form the compound, R is selected from the group consisting of benzylic or allyl groups and X is CPh.sub.2. A method of forming a glycocide from the compound is also disclosed.
REFERENCES:
patent: 4518711 (1985-05-01), Hruby et al.
Bodor, et al., "A Strategy for Delivering Peptides into the Central Nervous ystem by Sequential Metabolism," Science, vol. 257:1698-1700 (1992).
Borman, Stu, "Blood-Brain Barrier Bridged by Molecular Packaging Technique," C&EN, pp. 57-58 (Oct. 5, 1992).
Polt, Et Al., "General Methods for Alpha- or Beta-O-Ser/Thr Glycosides and Glycopeptides. Solid Phase Synthesis of O-Glycosyl Cyclic Enkephalin Analogs," ACS Journal published Dec. 16, 1992.
Szabo, et al., "O-Glycopeptides: A Simple beta-Stereoselective Glycosidation of Serine and Threonine Via A Favorable Hydrogen Bonding Pattern," Tetrahedron Letters, 32:58 (1991).
Polt, et al., "Alpha- and Beta-O-Glycosides via Nucleophilic Activation by Hydrogen Bond Acceptors. New Synthetic Methods for O-Linked Glycopeptides and Glycosphingolipids," American Chemical Society Abstract, published Mar. 2, 1992.
Huff Sheela J.
The Arizona Board of Regents on Behalf of the University of Ariz
Warden Jill
LandOfFree
Method for making amino acid glycosides and glycopeptides does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for making amino acid glycosides and glycopeptides, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for making amino acid glycosides and glycopeptides will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2014550