Method for making amino acid glycosides and glycopeptides

Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives

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530322, 530327, 530328, 530329, 530330, 530331, 536 179, 536 185, 562575, 564165, 564197, C07H 100, C07H 1500, C07K 500, C07K 700

Patent

active

057672547

ABSTRACT:
A compound of the formula ##STR1## is disclosed. X is selected from the group consisting of aryl, alkyl, imte ester, imino ester, amidine, azide, isocyanate, and dithiocarbonate. R' is a group selected from the group consisting of groups containing a hydroxyl moiety, groups containing a protected hydroxyl moiety, and groups containing an O-linked sugar. G is a carbon chain of 0-10 carbons and R is not a methyl group and is a group capable of removal under conditions compatible with glycopeptide synthesis. In a preferred form the compound, R is selected from the group consisting of benzylic or allyl groups and X is CPh.sub.2. A method of forming a glycocide from the compound is also disclosed.

REFERENCES:
patent: 4518711 (1985-05-01), Hruby et al.

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