Method for making amino acid glycosides and glycopeptides

Details Method for making amino acid glycosides and glycopeptides Method for making amino acid glycosides and glycopeptides

1995-06-06

1998-06-16

Peselev, Elli

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

530322, 530327, 530328, 530329, 530330, 530331, 536 179, 536 185, 562575, 564165, 564197, C07H 100, C07H 1500, C07K 500, C07K 700

Patent

active

057672547

ABSTRACT:
A compound of the formula ##STR1## is disclosed. X is selected from the group consisting of aryl, alkyl, imte ester, imino ester, amidine, azide, isocyanate, and dithiocarbonate. R' is a group selected from the group consisting of groups containing a hydroxyl moiety, groups containing a protected hydroxyl moiety, and groups containing an O-linked sugar. G is a carbon chain of 0-10 carbons and R is not a methyl group and is a group capable of removal under conditions compatible with glycopeptide synthesis. In a preferred form the compound, R is selected from the group consisting of benzylic or allyl groups and X is CPh.sub.2. A method of forming a glycocide from the compound is also disclosed.

REFERENCES:
patent: 4518711 (1985-05-01), Hruby et al.

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