Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Reexamination Certificate
2005-07-28
2009-08-11
Tsang, Cecilia (Department: 1654)
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
C530S330000, C530S329000, C530S324000, C514S002600, C514S012200
Reexamination Certificate
active
07572884
ABSTRACT:
The present invention related to a method of producing polypeptides in transformed host cells by expressing a precursor molecule of the desired polypeptide which are to be acylated in a subsequent in vitro step. The invention is also related to DNA-sequences, vectors and transformed host cells for use in the claimed method. Further, the present invention is related to certain precursors of the desired polypeptides and certain acylation methods. The invention provides a method for making polypeptides being preferentially acylated in certain lysine ε-amino groups.
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Balschmidt Per
Diers Ivan
Egel-Mitani Michi
Hoeg-Jensen Thomas
Markussen Jan
Audet Maury
Novo Nordisk A S
Tsang Cecilia
Walker Shelby J.
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