Chemistry: molecular biology and microbiology – Apparatus
Reexamination Certificate
2010-07-08
2011-11-22
Naff, David (Department: 1657)
Chemistry: molecular biology and microbiology
Apparatus
C435S002000, C435S004000, C435S041000, C435S183000, C435S174000, C435S325000, C435S243000, C435S289100, C435S307100, C436S547000, C530S300000, C530S350000, C536S022100
Reexamination Certificate
active
08062881
ABSTRACT:
Hydrophobic polymer surfaces whose level of protein binding is less than about 50-80 ng/cm2are achieved by: (1) applying a coating solution composed of a solvent and a non-ionic surfactant having a HLB number of less than 5 to the surface; and (2) drying the surface to remove the solvent and thereby bring the surfactant into direct contact with the hydrophobic polymer. The combination of a low HLB number and the drying step have been found to produce low binding surfaces which can withstand multiple washes with water and/or protein-containing solutions Alternatively, the low binding surfaces can be produced by applying the non-ionic surfactant to the mold surfaces which contact molten polymer and form the polymer into a desired shape, e.g., into a multi-well plate, a pipette tip, or the like. Further, the low binding surfaces may be produced by incorporating non-soluble, non-ionic surfactants having an HLB number of less than or equal to 10 into a polymer blend prior to molding the article.
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Bookbinder Dana Craig
Fewkes, Jr. Edward John
Griffin James Arthur
Smith Frances M.
Tennent David L.
Beall Thomas R.
Corning Incorporated
Naff David
Wilks Susan S.
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