Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1997-10-07
1999-11-02
Bawa, Raj
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424453, 424464, 424466, 424468, 424470, A61K 922
Patent
active
059765712
ABSTRACT:
A drug delivery system (10) includes a first capsule half (12) having an inner chamber (16) for containing a drug (18) therein. A plug (28) is disposed in a passageway (26) of the capsule half (12) for plugging the opening (24) thereof. The plug (28) is releasable from the passageway opening (24) upon the application of pressure from within the inner chamber (16). A pump mechanism, reactive with the external environment of the capsule half (12), causes an increase in pressure within the inner chamber (16) and forces the plug (28) out of the passageway (26) to release the drug (18) from the inner chamber (16) and out of the passageway (26). Thusly, after initial release of drug from a second capsule half (14) releasably mounted on the first capsule half (12), the first capsule half (12) provides a second pulse of drug release at a predetermined time after initial ingestion of the capsule. The invention further provides a method of manufacturing the drug delivery system (10) and method by which the drug delivery system (10) provides the drug to a body.
REFERENCES:
patent: 4773907 (1988-09-01), Urquhart et al.
patent: 4777049 (1988-10-01), Magruder et al.
patent: 4783337 (1988-11-01), Wong et al.
patent: 4865849 (1989-09-01), Conte et al.
patent: 5387421 (1995-02-01), Amindo et al.
Amidon Gordon L.
Crison John R.
Bawa Raj
Port Systems L.L.C.
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