Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – Attached to antibody or antibody fragment or immunoglobulin;...
Patent
1993-06-25
1995-11-21
Lacey, David L.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
Attached to antibody or antibody fragment or immunoglobulin;...
424 9341, 5303871, 5303872, 5303873, 53038822, 5303881, 5303913, 43524027, G01N 3358, A61K 5100, C07K 1628, C12N 512
Patent
active
054684684
ABSTRACT:
Potent neutralizing monoclonal antibodies to the human .alpha. PDGF receptor (.alpha. PDGFR) and fragments thereof are described. These monoclonal antibodies specifically bind to an epitope on .alpha. PDGFR, inhibits PDGF binding with PDGF, antagonizes PDGF, and does not bind .beta. PDGFR receptor. A hybridoma cell line producing such a monoclonal antibody, methods of in vivo imaging of a pathological conditions and methods of inhibiting the growth of a neoplasia expressing .alpha. PDGFR, which use these monoclonal antibodies are also described. In vitro assays for detecting the presence of .alpha. PDGFR and for evaluating the binding affinity of a test compound are also described.
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Aaronson Stuart A.
Jensen Roy A.
LaRochelle William J.
Pierce Jacalyn
Lacey David L.
Loring Susan A.
The United States of America as represented by the Secretary of
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