Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1975-09-29
1976-11-16
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424 19, 128260, A61K 900, A61K 926
Patent
active
039925188
ABSTRACT:
The present invention is concerned with a pharmaceutical delivery device comprising a biologically acceptable silicone polymer matrix having microsealed compartments of 10-200 microns throughout, wherein the microsealed compartments contain a pharmaceutical in a hydrophilic solvent system. The biologically acceptable silicone polymer matrix is formed by in situ cross linking of a liquid, biologically acceptable silicone polymer in an emulsion of pharmaceutical in the hydrophilic solvent system and liquid biologically acceptable silicone polymer. The biologically acceptable silicone polymer matrix is placed in a sealed or unsealed biologically acceptable polymer container. The rate of release of pharmaceutical is controlled by altering the solubility characteristics of the hydrophilic solvent system and/or the biologically acceptable polymer matrix, the rate of release being independent of time when the ratio of the partition coefficient of the pharmaceutical between the hydrophilic solvent system and biologically acceptable silicone polymer matrix to the solubility of the pharmaceutical in the hydrophilic solvent system is between 1 and 10.sup.-.sup.4 ml/mcg.
REFERENCES:
patent: 3279996 (1966-10-01), Long et al.
patent: 3518340 (1970-06-01), Raper
patent: 3545439 (1970-12-01), Duncan
patent: 3710795 (1973-01-01), Higuchi et al.
patent: 3797485 (1974-03-01), Urquhart
patent: 3832458 (1974-08-01), Merrill
patent: 3845761 (1974-11-01), Zaffaroni
patent: 3946106 (1976-03-01), Chien et al.
Chien Yie W.
Lambert Howard J.
G. D. Searle & Co.
McDonnell John J.
Rose Shep K.
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