Method for making a capsule-shaped tablet

Details Method for making a capsule-shaped tablet Method for making a capsule-shaped tablet

1991-11-04

1993-05-25

Theisen, Mary Lynn

Plastic and nonmetallic article shaping or treating: processes

Forming articles by uniting randomly associated particles

Stratified or layered articles

264112, 425345, A61K 920

Patent

active

052137384

ABSTRACT:
A method for making a multi-characteristic, bi-layer, capsule-shaped tablet by filling a die with a blend of one or more excipients and one or more active substances, including a first distinguishing ingredient, e.g., a first coloring agent, leveling the first blend and cleaning the die walls above the first blend, adding a second blend including a second distinguishing ingredient, e.g., a second coloring agent, and compressing both blends longitudinally in the die into the shape of a two component capsule. The tablet is coated with a clear coating, such as gelatin, to provide a solid medicament with the appearance of a gelatin capsule.

REFERENCES:
patent: 3158109 (1964-11-01), Stott
patent: 3275519 (1966-09-01), Glassman
patent: 3358687 (1967-12-01), Miley et al.
patent: 4139589 (1979-02-01), Beringer et al.
patent: 4353887 (1982-10-01), Hess et al.
patent: 4591500 (1986-05-01), Scapinelli
patent: 4820524 (1989-04-01), Berta
patent: 4921108 (1990-05-01), Berta
patent: 4990358 (1991-02-01), Berta
Pharmaceutical Sciences, 1985, pp. 1612-1620.
Remington's, Seventeenth Edition, pp. 443-446.
Pharmazeutischen Industrie, vol. 24, No. 9, 1962, pp. 417-422, Wagner, "Die Praxis der Mantel-und Mehrschichttablette."

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