Method for making a 2,6-dialkylphenol

Organic compounds -- part of the class 532-570 series – Organic compounds – Oxygen containing

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568425, 568426, 568431, 568432, 568782, C07C 3906, C07C 4500

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active

054751560

ABSTRACT:
A method is provided for converting a 2,4,6-trialkylphenol, such as mesitol, to a dialkylphenol, for example 2,6-dimethylphenol, by effecting the selective oxidation of the 2,4,6-trialkylphenol, followed by the deformylation of the resulting 3, 5-dialkyl-4-hydroxybenzaldehyde.

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Article--The Oxidation of 2,4,6-Trimethylphenol with Molecular Oxygen Catalyzed by a Copper (II)-Oxime or Copper (II)-Amine System, M. Shimizu et al. The Chemical Society of Japan-Bull. Chem. Soc. Jpn., 66 (1993) 251-257.
Article--Novel Oxidation of Phenols by a Copper (II) Complex Catalyst/O2 System, K. Takehira et al. Elsevier Science Publishers B.V., Amsterdam (1991) 279-284.
Article--A Novel Oxygenation of 2,4,6-Trimethylphenol to 3,5-Dimethyl-4-Hydroxybenzaldehyde by Dioxygen with Copper (II)-Amine Complex Catalyst, K. Takehira et al. Tetrahedrom Letters, vol. 31, No. 18 (1990) 2607-2608.
Substituted-5,6,7,8-tetrahydroonaphthalene Derivatives, MS Newman & HV Zahn--Contribution from the Chemical Laboratory of the Ohio State University (Jun. 1943) pp. 1097-1101.
Article-K. Fries, E. Brandes, E. Annalen-Zur Kenntnis der Chinhonmethide (1939) pp. 48-77 (Article is in German but also attached is notation referred to as Ref.3a on separate sheet).

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