Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1992-08-05
1993-11-23
Griffin, Ronald W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 184, 536 185, 536124, C08B 3700, C07H 100
Patent
active
052645703
ABSTRACT:
A method is provided for synthesizing 2-fluoro-2-deoxy-D-glucose having an [.sup.18 F] fluoride ion employing a dibenzo substituted aminopolyether (Kryptofix 222BB) as a phase-transfer reagent.
REFERENCES:
patent: 4794178 (1988-12-01), Coenen et al.
patent: 5169942 (1992-12-01), Johnson et al.
Abstract--Removal of the 2.2.2 cryptand (Kryptofix 2.2.2) from fluorine--18 labeled 2-deoxy-2-[.sup.18 F]fluoro-D-glucose, DL Alexoff et al Appl. Radiat. Isot., 42(12), 1189-93 (1991).
Article--Effects of Reaction Conditions on Rates Incorporation of No-Carrier Added F-18 Fluoride into Several Organic Compounds, ML Korguth et al--1988 by John Wiley & Sons, Ltd. pp. 360-381.
Article--Efficient Stereospecific Synthesis of No-Carrier-Added 2-[.sup.18 F]Fluor-2-Deoxy-D-Glucose Using Aminopolyether Supported Nucleophilic Substitution, K Hamacher et al--J. Nucl Med. 27:235-238 (1986).
Article--Recommendation for a Practical Production of [2-.sup.18 F]Fluror-2-Deoxy-D-Glucose, H. H. Coenen et al--Appl. Radial. Isot. vol. 38, No. 8 pp. 605-610 (1987).
Article--Robotic Production of 2-Deoxy-2[.sup.18 F]Fluror-D-Glucose: A Routine Method of Synthesis Using Tetrabutylammonium [.sup.18 F]Fluoride--J. W. Brodack et al--Appl. Radial. Isot. vol. 39, No. 7, pp. 699-703 (1988).
Article--Routine Production of 2-Deoxy-2[.sup.18 F]Fluoro-D-Glucose by Direct Nucleophilic Exchange on a Quaternary 4-Aminopyridinium Resin, S. A. Toorongian et al.--Nucl. Med Biol. vol. 17, No. 3 pp. 273-279 (1989).
Johnson Bruce F.
Maylotte Donald H.
Sabourin Cheryl L.
General Electric Company
Griffin Ronald W.
Pittman William H.
Teoli William A.
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