Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Patent
1994-07-18
1995-07-25
Robinson, Douglas W.
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
536 184, 536 185, C07H 100
Patent
active
054363250
ABSTRACT:
A method is provided for preparing [.sup.18 F]2-fluoro-2-deoxyglucose with an anion exchange resin by effecting an exchange reaction between an aqueous solution of [.sup.18 F]fluoride containing an alkali metal carbonate or bicarbonate, such as sodium bicarbonate, and an anion, such as bicarbonate or carbonate, on the anion exchange resin followed by the displacement reaction with 1,3,4,6-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-.beta.-D-mannopyranose to form the resulting 2-fluoro-2-deoxyglucose tetraacetate. Improved yields of the [.sup.18 F]2-fluoro-2-deoxyglucose are obtained when the alkali bicarbonate or carbonate is used in the target water.
REFERENCES:
Article-2-Deoxy-2-[18F]Fluoro-D-Glucose for Metabolic Studies: Current Status, JS Fowler and AP Wolf, Appl. Radiat. Isot. vol. 37, No. 8, pp. 663-668 (1986).
Article-Recommendation for A Pratical Production of [2-18F]Fluoro-2-Deoxy-D-Glucose, H. Coenen et al, Appl. Radiat. Isot. vol. 38, No. 8, pp. 605-610 (1987).
Article-Efficient Stereospecific Synthesis of No-Carrier-Added 2-[18F]-Fluoro-2-Deoxy-D-Glucose Using Aminopolyether Supported Nucleophilic Substitution, K. Hamacher et al, J. Nucl. Med. 27, 235 (86), p. 235238.
Article-Computer-aided Synthesis (CAS) of No-carrier-added 2-[18F]Fluoro-2-Deoxy-D-Glucose: An Efficient Automated System for the Aminopolyether-supported Nucleophilic Fluorination, K. Hamach et al, Appl. Radiat. Isot. vol. 41, No. 1 pp. 49-55 (1990).
Article-Robotic Production of 2-Deoxy-2-[18F]Fluoro-D-Glucose: A Routine Method of Synthesis Using Tetrabutylammonium [18F]Fluoride, J. W. Brodack et al. Appl. Raiiiat. Iost. vol. 39, No. 7, pp. 699-703 (1988).
Article-Routine Production of 2-Deoxy-2-[18F]Fluoro-D-Glucose by Direct Nucleophilic Exchange on a Quaternary 4-Aminopyridinium Resin, SA Toorongian et al., Nucl. Med. Biol. vol. 17, No. 3, pp. 273-279 (1990).
Johnson Bruce F.
Kiselev Maxim Y.
Ulin Johan
General Electric Company
Pittman William H.
Robinson Douglas W.
Wilson James O.
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