Drug – bio-affecting and body treating compositions – Fermentate of unknown chemical structure – Having a known elemental analysis
Patent
1984-05-22
1987-12-01
Rosen, Sam
Drug, bio-affecting and body treating compositions
Fermentate of unknown chemical structure
Having a known elemental analysis
530381, 530830, 530831, 530383, A61K 3516, C07K 1500
Patent
active
047103817
ABSTRACT:
A method for maintaining intact, non-degraded von Willebrand factor by preventing the action of calcium activated protease(s) responsible for degradation of the factor. The action of the calcium activated protease(s) may be avoided by removing the blood platelet source of the protease(s), by filtering or centrifugal separation, or by inactivating the protease with a chelating agent removing the calcium, by a protease inhibitor, or an alkylating agent.
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Kunicki Thomas J.
Montgomery Robert R.
Rosen Sam
The Blood Center of Southeastern Wisconsin
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