Method for maintaining intact, non-degraded factor VIII/von-Will

Details Method for maintaining intact, non-degraded factor VIII/von-Will Method for maintaining intact, non-degraded factor VIII/von-Will

1984-05-22

1987-12-01

Rosen, Sam

Drug, bio-affecting and body treating compositions

Fermentate of unknown chemical structure

Having a known elemental analysis

530381, 530830, 530831, 530383, A61K 3516, C07K 1500

Patent

active

047103817

ABSTRACT:
A method for maintaining intact, non-degraded von Willebrand factor by preventing the action of calcium activated protease(s) responsible for degradation of the factor. The action of the calcium activated protease(s) may be avoided by removing the blood platelet source of the protease(s), by filtering or centrifugal separation, or by inactivating the protease with a chelating agent removing the calcium, by a protease inhibitor, or an alkylating agent.

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