Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1994-04-18
1996-07-30
Feisee, Lila
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
209214, 2092231, 210695, 210222, 210767, 435 2, 435 5, 435 6, 435 71, 435 723, 435 731, 435 732, 436501, 436518, 436526, 436807, 436824, 436177, G01N 33567, G01N 33569
Patent
active
055410723
ABSTRACT:
Methods and devices are provided for separation of magnetic particles and/or magnetic-associated substances from non-magnetic associated substances and media. The methods are specifically applicable to biological separation, and utilize a phase phenomenon arising from mutual interactions between suspended magnetic particles and interactions with the suspension medium. The phenomenon is exploited to produce and maintain a distinct, structured phase of magnetic particles, or ferrophase, within a multi-phase liquid system. A ferrophase is established within a separation chamber prior to introducing therein a test sample containing the target substances to be separated. The formation of a ferrophase is used to transport target substances from regions of relatively low magnetic field gradient to regions of relatively high magnetic field gradient within a high-gradient magnetic separation apparatus. Such transport of the ferrophase is accomplished at greater speed than the transport of individual magnetic particles within a single liquid phase, thereby enabling a more effective separation of magnetic from non-magnetic components.
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Cronin William J.
Liberti Paul A.
Tang Weixin
Wang Yuzhou
Feisee Lila
Immunivest Corporation
Wolski Susan C.
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