Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Fungus – except allergen – or component thereof or substance...
Patent
1979-12-26
1981-12-22
Daus, Donald G.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Fungus, except allergen, or component thereof or substance...
26032656A, 2603265SA, 2603265D, 424267, 546270, 546274, A61K 3140, C07D22120, C07D20954
Patent
active
043071082
ABSTRACT:
A series of spiro-imide compounds and their base salts with pharmacologically acceptable cations are disclosed. These particular compounds are useful in therapy as agents for the control of certain chronic diabetic complications. Preferred member compounds include 2,3-dihydro-spiro-[1H-indene-1,3'-pyrrolidone]-2',5'-dione, 2,3-dihydro-spiro-[1H-indene-2,3'-pyrrolidine]-2',5'-dione, 3,4-dihydro-spiro-[2H-naphthalene-1,3'-pyrrolidine]-2',5'-dione, 3,4-dihydro-spiro-[2H-naphthalene-1,3'-piperidine]-2',6'-dione, 6-chloro-2,3-dihydro-spiro-[4H-1-benzopyran-4,3'-pyrrolidine]-2',5'-dione and 6,7-dihydro-spiro-[5H-benzo(b)thiophene-4,3'-pyrrolidine]-2',5'-dione. Methods for preparing these compounds from known starting materials are provided.
REFERENCES:
patent: 3507881 (1970-04-01), Sandberg
patent: 3821383 (1974-06-01), Sestand et al.
patent: 4147795 (1979-04-01), Sarges
patent: 4177282 (1979-12-01), Sarges
patent: 4209527 (1980-06-01), Sarges
patent: 4235911 (1980-11-01), Sarges
Faust et al., J. Am. Pharm. Assn. vol. XLVI, No. 2, pp. 118-124 (1957).
Belletire John L.
Sarges Reinhard
Daus Donald G.
Knuth Charles J.
Murphy Francis X.
Pfizer Inc.
Richardson Peter C.
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