Method for lowering serum cholesterol employing a phosphorus con

Details Method for lowering serum cholesterol employing a phosphorus con Method for lowering serum cholesterol employing a phosphorus con

1991-04-01

1992-10-20

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Phosphorus containing other than solely as part of an...

514 89, 514 90, 514 91, 514 94, A61K 31675

Patent

active

051570254

ABSTRACT:
A method is provided for lowering serum cholesterol and thereby inhibiting fatty streak lesions of atherosclerosis by administering to a patient a phosphorus-containing ACE inhibitor, such as fosinopril or ceronapril, alone or in combination with a cholesterol lowering drug, such as pravastatin.

REFERENCES:
patent: 4337201 (1982-06-01), Petrillo
patent: 4452790 (1984-06-01), Karanewsky et al.
patent: 5061694 (1991-10-01), Aberg et al.
Roelen, H. C. P. et al., J Med Chem 34(3):1036-1042 1991 (see p. 1037).
Zorn, J. et al., "Prevention of Arteriosclerotic Lesions with Calcium Antagonists of Captopril in Differenent Rat Hypertension Models," J. Cardiovasc. Pharmacol. vol. 12 (Suppl 6), 1988.
Someya, N. et al., "Suppressive Effect of Captopril on Platelet Aggregation in Essential Hypertension," J. Cardiovasc. Pharmacol. 6:840-843, 1984.
Mizuno, K. et al. "The effects of the angiotensin I-converting enzyme inhibitor, captopril, on serum lipoperoxides level and the renin-angiotensin-aldosterone and Kallikrein-kinin systems in hypertensive patients," Nippon Naibunpi Gakkai Zasshi, Feb. 20, 1984.
Mizuno, K. et al., "Acute effects of captopril on serum lipid peroxides level in hypertensive patients," Tohoku J. Exp. Med., May, 1984, 143(1) 127-8.
Overturf, M. et al., Atherosclerosis, 59:283-299, 1986.
Cecil, Textbook of Medicine, 16 Ed., pp. 239 to 241.
Keilani et al., "Sustained Amelioration of Proteinuria and Lipid Profile Abnormalities in Nephrotic Patients with Renal Impairment Treated with Fosinopril."
Brenner et al., "The Kidney," vol. II, 1981, pp. 1411-1412.
Seldin et al, "The Kidney, Physiology and Pathophysiology," vol. 2, 1985, pp. 1924-1926.

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