Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Cyclopentanohydrophenanthrene ring system doai
Patent
1996-10-30
1998-06-30
Jordan, Kimberly
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Cyclopentanohydrophenanthrene ring system doai
514824, 514866, A61K 3156
Patent
active
057734321
ABSTRACT:
A method of lowering plasma levels of Lp(a) or inhibiting the generation of apo(a) in a human by administering an effective amount of a compound of formula (I): ##STR1## wherein: R.sup.1 is hydrogen or alkyl;
REFERENCES:
patent: 4133814 (1979-01-01), Jones et al.
patent: 4418068 (1983-11-01), Jones
patent: 5489611 (1996-02-01), Lee et al.
patent: 5496828 (1996-03-01), Cullinan
patent: 5496851 (1996-03-01), Grinnell
Frazer, K. et al., Nature Genetics (1995) 9:424-431.
Kim et al., Arteriosclerosis and Thrombosis (1994) 14(2):275-281.
Brown et al. Arteriosclerosis Thromb (1993).
Anwar et al. (1993) Nephrol. Dial. Transplant. 8:71-74.
Heller et al., Diabetes Care (1993) 16(5):819-823.
Crook et al.. Atherosclerosis (1992) 92:41-47.
Radar et al. JAMA (1992) 267(8):1109-1112.
Boerwinkle et al., J. Clin. Invest. (1992) 90:52-60.
Lawn et al., Nature (1992) 360: 670-672.
Muller et al., German J. Opthalmol (1992) 1:338-341.
Tyrell et al., J. of Int. Medicine, (1992) 232:349-352.
Kapelrud et al., Br. Med. J. (1991) 303:675-678.
Mosca, et al., Circulation (1991) 84(4), Suppl II: 2169.
Muesing et al., Arteriosclerosis Thromb. (1991) 11(95):1452(a).
Farish et al., Br. Med J. (1991) 303:694.
Meilahn et al., Circulation (1991) 84(4), Suppl. II: 2170 (abstract).
Srinivasan, et al., Circulation (1991) 84(1):160-167.
Scanu et al., J. Clin. Invest. (1990) 85:1709-1715.
Bruckert et al., JAMA (1990) 263(1):35-36.
Sandkamp et al., Academic Press, Inc. (1990) 205-210.
Davis et al., C.V.D. (1990) 25 (abstract).
Utermann, Science (1989) 246:904-910.
Hajjar et al., Nature (1989) 339;303-305.
Harpel et al., Proc. Natl. Acad. Sci. USA (1989) 86:3847-3851.
Kraft et al., J. Clin. Invest. (1989) 83:137-142.
Tomlinson et al., J. Biol. Chem. (1989) 264(10):5957-5965.
Scanu, Arch. Pathol. Lab. Med. (1988) 112:1045-1047.
Hoff et al., Circulation (1988) 77:1238-1244.
Karadi et al., Biochim, Biophys. Acta (1988) 960:91-97.
McLean et al., Nature (1987) 330:132-137.
Rhoades, et al., JAMA (1986) 256(18):2540-2544.
Dahleen et al., Circulation (1986) 74(4):758-765.
Armstrong et al., Atherosclerosis (1986) 62:249-257.
Zechner et al., Metabolism (1986) 35:333-336.
Schriewer et al., J. Clin. Chem. Clin. Biochem. (1984) 22:591-596.
Albers et al., Biochim. Biophys. Acta (1984) 795:293-296.
Kostner, Atherosclerosis (1981) 38:51-61.
Krempler et al., J. Clin. Invest. (1980) 65:148301490.
Kauser Katalin
Rubanyi Gabor M.
Jordan Kimberly
Roth Carol J.
Schering Aktiengesellschaft
LandOfFree
Method for lowering plasma levels of lipoprotein(a) does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for lowering plasma levels of lipoprotein(a), we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for lowering plasma levels of lipoprotein(a) will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1859472