Surgery – Truss – Pad
Patent
1986-09-10
1988-11-08
Cohen, Lee S.
Surgery
Truss
Pad
128659, A61B 1000
Patent
active
047828404
ABSTRACT:
The present invention is addressed to a method for the improved localization, differentiation, and removal of neoplastic tissue in animals. In particular, one aspect of the present invention involves a surgical procedure wherein an animal suspected of containing neoplastic tissue is surgically accessed and the tissue therein examined visually and by palpation for evidence of neoplastic tissue. The improved methodology commences with the administering to the animal of an effective amount of a labelled antibody specific for neoplastic tissue and labelled with a radioactive isotope exhibiting specific photon emissions of energy levels. Next, and importantly, the surgial procedure is delayed for a time interval following said administering for permitting the labelled antibody to preferentially concentrate in any neoplastic tissue present in the animal so as to increase the ratio of photon emissions from neoplastic tissue to background photon emissions in said animal. Thereafter, an operative field of the animal is surgically accessed and tissue within the operative field to be examined for neoplastic tissue has the background photon emission count determined. Once the background photon emission account for tissue within the operative field has been determined, a handheld probe is manually positioned within the operative field adjacent tissue suspected of being neoplastic. The probe is configured for fascile hand positioning and maneuvering within the operative field of the animal. The probe is characterized by having a collimatable radiation detector having a selective photon entrance and having an output deriving discrete signals responsive to photon emissions when said entrance is positioned immediately adjacent thereto. The probe further comprises amplifier means having an input coupled with said radiation detector output and responsive to said discrete signals to provide corresponding amplified output pulses. Finally, the probe comprises readout means responsive to said output pulses and actuable to an initial condition for commencing the provision of a perceptible indication of an indicia corresponding to the number of said output pulses received. From the perceptible indication, the extent of tissue exhibiting a number of output pulses having a value above background output pulses is determined and such determined tissue removed surgically. Thereafter, the probe is manually positioned adjacent tissue surrounding the surgically removed tissue to determined from said perceptible indication whether any of said surrounding tissue still exhibits a number of output pulses having a value above said background output pulses. Any adjacent tissue surrounding the initial surgically removed tissue which does exhibit an increased number of output pulses is surgically removed additonally. Thereafter, the margins again are examined with the probe in order to ensure that all tissue exhibiting a number of output pulses having a value above the background output pulses has been removed.
REFERENCES:
patent: 3665916 (1972-05-01), Kobayashi et al.
patent: 3670719 (1972-06-01), Kobayashi et al.
patent: 3827427 (1974-08-01), Knoll
patent: 4015592 (1977-04-01), Bradley-Moore
patent: 4092980 (1978-06-01), Frank et al.
patent: 4243884 (1981-01-01), Avera
patent: 4311688 (1982-01-01), Burchiel et al.
patent: 4444744 (1984-04-01), Goldenberg
patent: 4479931 (1984-10-01), Lambrecht et al.
patent: 4595014 (1986-06-01), Barrett et al.
Siffert, P.: "Current Possibilities and Limitations of Cadmium Telluride Detectors", Nuc. Inst. & Methods 150:1-12, 1978.
Serreze, H. B.; Entine, G.; Bell, R. O.; and Wald, F. V.: "Advance in CdTe Gamma-Ray Detectors" Trans. in Nuclear Science, vol. NS21 , No. 1, pp. 404-407 (Feb., 1974).
"Cadmium Telluride-A Breakthrough in Nuclear Radiation Detection", Marketing Brochure of Radiation Monitoring Devices, Inc., Watertown, Mass., Undated.
"Nuclear Instruments", a Marketing Brochure by Radiation Monitoring Devices, Inc., Watertown, Mass., Copyright 1981.
"A-225 Charge Sensitive Preamplifier & Shaping Amplifier", a Marketing Brochure by Amptek, Inc., Bedford, Mass., Apr. 1983.
"Technical and Clinical Characteristics of a Surgical Biopsy Probe" by Harvey and Lancaster, Journal of Nuclear Medicine, vol. 22, pp. 184-186, 1981.
"Role of Radionuclide Imaging in Osteoid Osteoma" by Lisbona and Rosenthall, AJR: 132, Jan. 1979.
"Scintigraphic Appearances of Osteoid Osteoma" by Smith et al., Nuclear Medicine, vol. 137, Oct. 1980.
"Intraoperative Skeletal Scintigraphy for Localization of Osteoid-Osteoma in the Spine", Rinsky et al., Journal of Bone and Joint Surgery, vol. 62-A, Jan. 1980.
"Sixty Second-Look Procedures Indicated Primarily by Rise in Serial Carcinoembryonic Antigen" by Martin, Jr. et al., Journal of Surgical Research, 28, 389-394 (1980).
Martin, Jr. Edward W.
Thurston Marlin O.
Cohen Lee S.
Hanley John C.
Neoprobe Corporation
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