Method for local immunization against dental caries

Details Method for local immunization against dental caries Method for local immunization against dental caries

1973-06-20

1976-01-06

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Whole live micro-organism, cell, or virus containing

Genetically modified micro-organism, cell, or virus

424 50, A61K 3902, A61K 500, A61K 726

Patent

active

039313980

ABSTRACT:
Immunization against dental caries by local administration, in the vicinity of the oral mucosa of an animal susceptible to dental caries, of a vaccine containing a polyfructan or polyglucan polysaccharide, or a levansucrase or dextransucrase enzyme. The polysaccharides may be administered in purified form, or may be in the form of dead cells of the streptococci by which they are elaborated. Polyglucan polysaccharides so useful are produced by elaboration of strains of the species S.mutans and S.sanguis, while the polyfructan which may be incorporated in the vaccine may be an elaboration product of Streptomyces Strain SS2.

REFERENCES:
Chemical Abstracts (1), Vol. 76, entry 135,658k, 1972.
Chemical Abstracts (2), Vol. 77, entry 3696g, 1972.
Chemical Abstracts (3), Vol. 78, entry 95990v, 1973.
Hayashi et al., J. Dent. Res., Vol. 51, pp. 436-442, Mar.-Apr., 1972.

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