Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or...
Reexamination Certificate
2005-10-04
2005-10-04
Housel, James (Department: 1648)
Chemistry: molecular biology and microbiology
Virus or bacteriophage, except for viral vector or...
C435S239000, C424S209100, C424S226100, C424S204100
Reexamination Certificate
active
06951752
ABSTRACT:
The present invention provides improved methods of production of viral antigen on a culture of adherent cells bound to a microcarrier, wherein the methods provide for increased viral antigen yield per culture medium volume. The invention is also directed to a cell culture biomass of adherent cells having increased cell density and microcarrier concentration compared to the respective confluent cell culture.
REFERENCES:
patent: 4525349 (1985-06-01), Montagnon et al.
patent: 5994134 (1999-11-01), Giroux et al.
patent: 6048537 (2000-04-01), Violay et al.
patent: 6100061 (2000-08-01), Reiter et al.
patent: 6344354 (2002-02-01), Webster et al.
patent: 6455298 (2002-09-01), Groner et al.
patent: WO 91/09935 (1991-07-01), None
patent: WO 96/15231 (1996-05-01), None
Butler;Animal Cell Biotechnology; Ed. R.E. Spier and J.B. Griffiths; vol. 3, p. 284-303 (1988).
Caij, et al.;High Titre Hog Cholera Virus Production on Cytodex 3® Microcarrier Cultures; Archives of Virology; vol. 105, p. 113-118 (1989).
Cinati Jr., et al.;Protein-Free Culture of Vero Cells: A Substrate for Replication of Human Pathogenic Viruses; Cell Biology International; vol. 17, No. 9, p. 885-895 (1993).
Fiorentine, et al.;Production of Herpesvirus of Turkeys In Microcarrier Culturing System-A New Method for Production of Vaccine Against Marek's Disease; Develop Biol. Standard; vol. 60, p. 421-430 (1985).
Griffiths, et al.;The Development and Use of Microcarrier and Glass Sphere Culture Techniques for the Production of Herpes Simplex Viruses; Develop Biol. Standard; vol. 50, p. 103-110 (1982).
Holzer, et al.;Construction of a Vaccinia Virus Deficient in the Essential DNA Repair Enzyme Uracil DNA Glycosylase by a Complementing Cell Line; Journal of Virology; vol. 71, p. 4997-5002 (Jul. 1997).
Kessler, et al.;Suitability of MDCK Cells Grown in a Serum-Free Medium for Influenza Virus Production; Dev. Biol. Stand.; vol. 98, p. 13-21 (1999).
Kistner, et al.;Development of a Mammalian Cell(Vero)Derived Candidate Influenza Virus Vaccine; Vaccine; vol. 16, No. 9/10, p. 960-968 (1998).
Kistner, et al.;Development of a Vero Cell-Derived Influenza Whole Virus Vaccine; Dev. Biol. Stand.; vol. 98, p. 101-110 (1999).
Merten, et al.;Evaluation of the New Serum-Free Medium(MDSS2)for the Production of Different Biologicals: Use of Various Cell Lines; Cytotechnology; vol. 14, p. 47-59 (1994).
Merten, et al.;Production of Influenza Virus in Serum-Free Mammalian Cell Cultures; Dev. Biol. Stand.; vol. 98, p. 23-37 (1999).
Miller, et al.;Microbeads and Anchorage-Dependent Eukaryotic Cells: The Beginning of a New Era in Biotechnology; Advances in Biochemical Engineering/Biotechnology; vol. 39, p. 73-95 (1989).
Reuveny, et al.;Newly Developed Microcarrier Culturing Systems—An Overview; Develop. Biol. Standard; vol. 60, p. 243-253 (1985).
Sanford, et al.;The Measurement of Proliferation in Tissue Cultures by Enumeration of Cell Nuclei; J. Natl. Cancer Inst.; vol. 11, p. 773-795 (1951).
Seewoster, et al.;Cell Size Distribution as a Parameter for the Predetermination of Exponential Growth During Repeated Batch Cultivation of CHO Cells; Biotechnology and Bioengineering; vol. 55; p. 793-797 (1997).
Van Wezel;Growth of Cell-Strains and Primary Cells on Micro-Carriers in Homogeneous Culture; Nature; vol. 216, p. 64-65 (1967).
Van Wezel, et al.;Large Scale Cultivation of Animal Cells in Microcarrier Culture; Process Biochemistry; vol. 13, p. 6-8 (1978).
Widell, et al.;A Microcarrier Cell Culture System for Large Scale Production of Hepatitis A Virus; Journal of Virological Methods; vol. 8, p. 63-71 (1984).
Kistner et al., “Development of a novel influenza vaccine derived from a continuous cell line!”,Linz18:1:50-54 XP001146190 (2001), english abstract only. SBC Jan. 16, 2004.
Kistner et al., “Novel Mammalian Cell (Vero) Derived Influezy Virus Vaccine: Development, Characterization and Individual Scale Production”,Wiener Klinische Wochenschrift111:5: 207-214, XP000909353 (1999).
Barrett et al., “Large-Scale Production and Purification of a Vaccinia Recombinant-Derived HIV-1 gp 160 and Analysis of Its Immunogenicity”,Aids Research and Human Retroviruses5:2: 159-172, XP001064669 (1989).
Percheson et al., “A Phase I, Randomized Controlled Clinical Trial to Study the Reactogenicity and Immunogenicity of a New Split Influenza Vaccine Derived from a Non-Tumorigenic Cell Line”,Developments in Biological Standardization98: 127-132, XP009008177 (1999).
Sharkey et al., “Ross River Virus Glycoprotein-Pseudotyped Retroviruses and Stable Cell Lines for Their Production”,Journal of Virology75:6: 2653-2859, XP002235506 (2001).
Mundt Wolfgang
Reiter Manfred
Bexter Healthcare S.A.
Chen Stacy B.
Engleman Patrick S.
Housel James
Townsend and Townsend & Crew
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