Organic compounds -- part of the class 532-570 series – Organic compounds – Carbohydrates or derivatives
Reexamination Certificate
2006-08-15
2006-08-15
Jiang, S. Anna (Department: 1623)
Organic compounds -- part of the class 532-570 series
Organic compounds
Carbohydrates or derivatives
C536S055300, C536S026200
Reexamination Certificate
active
07091334
ABSTRACT:
The present invention provides new methods for the synthesis of the therapeutic dinucleotide, P1,P4-di(uridine 5′)-tetraphosphate, and demonstrates applicability to the production of large quantities. The methods of the present invention substantially reduce the time period required to synthesize diuridine tetraphosphate, preferably to three days or less. The novel tetrammonium and tetrasodium salts of P1,P4-di(uridine 5′)-tetraphosphate (Formula I) prepared by these methods are stable, soluble, nontoxic, and easy to handle during manufacture.wherein:X is Na, NH4or H, provided that all X groups are not H.
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Pendergast William
Yerxa Benjamin R.
Crane L. E.
Howrey LLP
Inspire Pharmaceuticals Inc.
Jiang S. Anna
Kung Viola T.
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