Chemistry of inorganic compounds – Radioactive
Reexamination Certificate
2005-12-27
2005-12-27
Silverman, Stanley S. (Department: 1754)
Chemistry of inorganic compounds
Radioactive
C423S561100, C424S001110, C424S001650
Reexamination Certificate
active
06979431
ABSTRACT:
A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.
REFERENCES:
patent: 3873680 (1975-03-01), Jackson et al.
patent: 3928552 (1975-12-01), Winchell et al.
patent: 4208398 (1980-06-01), Kubiatowicz et al.
patent: 5662882 (1997-09-01), Brodack et al.
patent: 6099822 (2000-08-01), Ozker et al.
patent: 6344178 (2002-02-01), Alberto et al.
patent: 2003/0120046 (2003-06-01), Lee et al.
patent: 2003/0228255 (2003-12-01), Park et al.
patent: WO 98/488848 (1998-11-01), None
patent: WO 01/70724 (2001-09-01), None
An article entitled “Neutral and Stereospecific Tc-99m Complexes: . . . ,” By Zhuang et al., published by Nuclear Medicine & Biology, vol. 26, pp. 217-224, 1999.
An article entitled “Small and Neutral TcvO BAT Bisaminoethanethiol (N2S2) . . . ,” By Oya et al., published by Nuclear Medicine & Biology, vol. 25, pp. 135-140, 1998.
An article entitled “Preparation of 99mTc-N2S2 Conjugates of . . . ,” By Dezutter et al., published by Journal of Labelled Compounds and Radiopharmaceuticals, vol. 42, pp. 309-324, 1999.
Choi Sang Mu
Choi Sun Ju
Gwon Hui Jeong
Han Kwang Hee
Hong Young Don
Bachman & LaPointe P.C.
Hertzog Ardith E.
Korea Atomic Energy Research Institute
Silverman Stanley S.
LandOfFree
Method for labelling technetium or rhenium using borohydride... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method for labelling technetium or rhenium using borohydride..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method for labelling technetium or rhenium using borohydride... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3519663