Method for labeling the 3' terminus of a synthetic oligonucleoti

Details Method for labeling the 3' terminus of a synthetic oligonucleoti Method for labeling the 3' terminus of a synthetic oligonucleoti

1992-08-24

1995-03-28

Rollins, John W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 253, 526336, 501 33, C07H 100, C07H 2104, C03C 1200, C07C21102

Patent

active

054018374

ABSTRACT:
A method for derivatizing and labeling the 3'-terminus of an oligonucleotide during solid phase synthesis comprising the use of a multifunctional reagent whose preferred structure is shown below. ##STR1## wherein CPG is controlled pore glass beads, Fmoc is 9-fluorenylmethyoxycarbonyl, and the alkylamine contains 1 to 50 carbon atoms.

REFERENCES:
patent: 4458066 (1984-07-01), Caruthers et al.
patent: 4849513 (1989-07-01), Smith et al.

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